Inositol-Triphosphate 3 Receptor | InsP3R
Family:
Inositol-Triphosphate 3 Receptor
Topology and members:
The InsP3R contains six transmembrane regions. Four subunits are forming a homotetramer in humans.Three different members are known in humans: InsP3R type 1 - InsP3R type 3.
Regulation and Function:
InsP3R is a membrane glycoprotein complex acting as Ca2+ channel, activated by inositol-triphosphate. InsP3R is an intracellular channel that mediates calcium release from the endoplasmic reticulum and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory.
Data and Applications
Inositol-Triphosphate 3 Receptor (IP3) - Reconstitution
Vesicle Prep Pro data and applications:
Data were kindly supplied by Prof. Colin Taylor, University of Cambridge, Cambridge, UK.
Representative traces of the IP3 (inositol-triphosphate) receptor were recorded at different voltages in the presence of IP3 (0.2 mM free Ca2+ and 1 mM Na2ATP, 140 mM KCl). Addition of 2 μM IP3 on the cytosolic side evoked openings of the IP3 receptor.
Publications
2016 - Pore architecture of TRIC channels and insights into their gating mechanism
Port-a-Patch and Vesicle Prep Pro publication in Nature (2016)
Authors:
Yang H., Hu M., Guo J., Ou X., Cai T., Liu Z.