• Kir4.1

    Representative current voltage relationship plots, measured on the Patchliner

    Lewis et al. (2009)

Kir4.1 | Potassium Voltage-Gated Channel Subfamily J Member 10

Inward-rectifier potassium ion channel

Seven families channels demonstrate robust inward rectification: Kir1.1; Kir2.1 - Kir2.4; Kir3.1 - Kir3.4, Kir4.1 - Kir4.2; Kir5.1, Kir6.1 - Kir6.2; Kir7.1

The channel protein contains two membrane spanning alpha helices denoted as M1 and M2. Four identical subunits form a functional homotetramer, heterotetramers can combine with members of the same subfamily

Kir4.1 Background Information

Kir4.1 is an ATP-dependent inwardly rectifying potassium channel. It is expressed in the Stria vascularis and is essential for formation of the endolymph, the fluid that surrounds the mechanosensitive stereocilia of the sensory hair cells that make hearing possible. In the kidney, together with Kir5.1, the channel mediates basolateral K+ recycling in distal tubules; this process is critical for Na+ reabsorption at the tubules.


Human Protein:
UniProt P78508

Brain (astrocytes), kidney, inner ear, CD8 T cells

Function/ Application:
Responsible for the potassium buffering action of glial cells in the brain, mediates basolateral K+ recycling in distal tubules

Epilepsy, Ataxia, Sensorineural deafness, Tubulopathy, EAST syndrome (Gitelman syndrome phenotype), seizures, sensorineural deafness, mental retardation, and electrolyte imbalance (SESAMES)

Forms heteromers with Kir5.1, Kir4.2 and Kir2.1. It interacts with interleukin 16, MAGI1, PATJ, DLG1, DLG4, Gamma-aminobutyric acid B receptor 2

Barium chloride, Cesium chloride, Tertiopin-Q, Nortriptyline, Tolbutamide

Patch clamp

Recommended Reviews:
Kubo et al. (2005) International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 57(4):509-526


2011 - Development of a selective small-molecule inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel

icon pl  Patchliner publication in Molecular Pharmacology (2011)

Bhave G., Chauder B.A., Liu W., Dawson E.S., Kadakia R., Nguyen T.T., Lewis L.M., Meiler J., Weaver C.D., Satlin L.M., Lindsley C.W., Denton J.S.

2009 - High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1

icon pl  Patchliner publication in Molecular Pharmacology (2009)

Lewis L.M., Bhave G., Chauder B.A., Banerjee S., Lornsen K.A., Redha R., Fallen K., Lindsley C.W., Weaver C.D., Denton J.S.

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