KV1.1 | Shaker Related Potassium Channel Member 1

K_V1.1 is a delayed-rectifier voltage gated potassium channel that mediates transmembrane potassium transport in excitable membranes. It Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. It is suggested that heteromeric potassium channels composed of both K_V1.1 and K_V1.2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neuron

Gene:
KCNA1

Human Protein:
UniProt Q09470

Tissue:
CNS, kidney

Function/ Application:
K_V1.1 contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. The channel regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons. The regulation of the hyperexcitability in myelinated axons of the vagus nerve may contribute to the regulation of heart contraction. Furthermore, the channel plays a role in the reabsorption of Mg²⁺ in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential

Pathology:
Mutations in this gene cause episodic ataxia type 1 (EA1) and Myokymia isolated 1 (MK1), the Isaacs syndrome is a result of an autoimmune reaction against the Kv1.1 ion channel

Interaction:
KCNA1 can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well. Channel properties are modulated by cytoplasmic beta subunits (KCNAB1 and KCNAB2) that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. Furthermore the channel can interact with: Futher interactions: ANK3, KCNRG, GNB1, GNG2, STX1A, LGI1, DLG1, DLG2 and DLG4

Modulator:
4-aminopyridine (4-AP), tetraethylammonium (TEA), dendrotoxin (DTX), Amitriptyline, Retigabine

Assays:
Patch Clamp: whole cell mode

Recommended Reviews:
Gutman et al. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57(4):473-508

Useful website:
https://channelpedia.epfl.ch/ionchannels/2