KV1.1 | Shaker Related Potassium Channel Member 1
Family:
Potassium channels
Subgroups:
Shaker (KV1.1–KV1.8), Shab (KV2.1-KV2.2), Shaw (KV3.1–KV3.4), Shal (KV4.1–KV4.3), KQT like (KV7.1–KV7.5), Eag related (KV10.1-KV10.2), Erg related (KV11.1–KV11.3), Elk related (KV12.1)
Topology:
Contains six transmembrane domains (S1–S6), four single subunits form a pore, homotetramers and heterotetramers are possible.
KV1.1 Background Information
KV1.1 is a delayed-rectifier voltage gated potassium channel that mediates transmembrane potassium transport in excitable membranes. It Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. It is suggested that heteromeric potassium channels composed of both KV1.1 and KV1.2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neuron
Gene:
KCNA1
Human Protein:
UniProt Q09470
Tissue:
CNS, kidney
Function/ Application:
KV1.1 contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. The channel regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons. The regulation of the hyperexcitability in myelinated axons of the vagus nerve may contribute to the regulation of heart contraction. Furthermore, the channel plays a role in the reabsorption of Mg2+ in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential
Pathology:
Mutations in this gene cause episodic ataxia type 1 (EA1) and Myokymia isolated 1 (MK1), the Isaacs syndrome is a result of an autoimmune reaction against the Kv1.1 ion channel
Interaction:
KCNA1 can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well. Channel properties are modulated by cytoplasmic beta subunits (KCNAB1 and KCNAB2) that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. Furthermore the channel can interact with: Futher interactions: ANK3, KCNRG, GNB1, GNG2, STX1A, LGI1, DLG1, DLG2 and DLG4
Modulator:
4-aminopyridine (4-AP), tetraethylammonium (TEA), dendrotoxin (DTX), Amitriptyline, Retigabine
Assays:
Patch Clamp: whole cell mode
Recommended Reviews:
Gutman et al. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57(4):473-508
Useful website:
https://channelpedia.epfl.ch/ionchannels/2