KV1.2 | Shaker Related Potassium Channel Member 2

Family:
Potassium channels

Subgroups:
Shaker (KV1.1–KV1.8), Shab (KV2.1-KV2.2), Shaw (KV3.1–KV3.4), Shal (KV4.1–KV4.3), KQT like (KV7.1–KV7.5), Eag related (KV10.1-KV10.2), Erg related (KV11.1–KV11.3), Elk related (KV12.1)

Topology:
Contains six transmembrane domains (S1–S6), four single subunits form a pore, homotetramers and heterotetramers are possible.

KV1.2 Background Information

KV1.2 is a delayed rectifier voltage gated potassium channel found in almost all cell types. This member of the shaker-related subfamily contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It's function is to allow nerve cells to efficiently repolarize following an action potential. It mainly contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. KCNA2 (gene) can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNA2 or other alpha subunits, creating a functionally diverse range of channel complexes.

Gene:
KCNA2

Human Protein:
UniProt P16389

Tissue:
Brain (neurons), cardiac and smooth muscle tissue, retina, pancreas

Function/ Application:
Excitability of neurons and muscle

Pathology:
Epileptic Encephalopathy, Undetermined Early-Onset Epileptic Encephalopathy, ataxia, neuropathic pain

Interaction:
Forms homotertamers or heterotetramers with Kv1.1, Kv1.5, Kvβ1, Kvβ2. Also interacts with PSD95, RhoA, Caspr2, SAP97, SNAP95 I 

Modulator:
Margatoxin, Dendrotoxin, Tityustoxin Kα Hongotoxin-1, Urotoxin

Assays:
Patch Clamp: whole cell mode

Recommended Reviews:
Gutman et al. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57(4):473-508

Useful website:
https://channelpedia.epfl.ch/ionchannels/2

Publications

2020 - Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

icon pl   Patchliner publication in Biochemical Pharmacology (2020)

Authors:
Luna-Ramirez K., Csoti A., McArthur J.R., Chin Y.K.Y., Anangi R., del Carmen Najera R., Possani L.D., King G.F., Panyi G., Yu H., Adams D.J., Finol-Urdaneta R.K.

2019 - A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

 icon pl   Patchliner publication in Frontiers in Cellular Neuroscience (2019)

Authors:
Ranjan R., Logette E., Marani M., Herzog M., Tâche V., Scantamburlo E., Buchillier V., Markram H.

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.