KV10.1 | EAG1 | Eag Related Potassium Channel Member 1

Family:
Potassium channels

Subgroups:
Shaker (KV1.1–KV1.8), Shab (KV2.1-KV2.2), Shaw (KV3.1–KV3.4), Shal (KV4.1–KV4.3), KQT like (KV7.1–KV7.5), Eag related (KV10.1-KV10.2), Erg related (KV11.1–KV11.3), Elk related (KV12.1)

Topology:
Contains six transmembrane domains (S1–S6), four single subunits form a pore, homotetramers and heterotetramers are possible.

 

KV10.1 Background Information

KV10.1, also known as human ether à-go-go1 protein or EAG1, is the pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Upon a depolarization, a slowly activating noninactivating outward current is elicited. Upon repolarization a small tail current occurs. EAG1 is expressed almost exclusively in brain tissue and is involved in cell excitability, memory processes, and cell proliferation. Their expression in over 70% of human tumours makes them an attractive diagnostic and therapeutic target treatment of prostate cancer: The Eag1 K+ channel is especially thought to be involved in the pathophysiological processes of prostate cancer, and is expected to be a valuable target for the diagnosis and treatment of prostate cancer.

Gene:
KCNH1

Human Protein:
O95259

Tissue:
Brain (cortex, hippocampus, caudate, putamen, amygdala and weakly in substantia nigra, retina), kidney, lung, pancreas, bone marrow mesenchymal stem cells, heart

Function/ Application:
Cell proliferation, cell excitability, transformation of epithelial cells, mediates IKNI current in myoblasts

Pathology:
Cancer, Temple-Baraitser Syndrome, Zimmermann-Laband Syndrome 1, myasthenic syndrome, congenital 5 , acute contagious conjunctivitis

Interaction:
KV2.1, epsin, KCR1, ICA, KV10.2, ALG10B, CaM, slop, RABEP1, CTTN

Modulator:
Quinidine, astemizole, E-4031, terfenadine, dofetilide, haloperidol, imipramine,

Assays:
Patch Clamp: whole cell, state- and use-dependance, temperature control

Recommended Reviews:
Gutman et al. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57(4):473-508

Data and Applications

hEAG (hKv10.1) - Internal Application of TEA

application heag 1

icon pap   Port-a-Patch data and applications:
Data were kindly provided by Walter Stühmer, MPI for exp. Med., Göttingen.

Block of hEAG whole cell currents after the internal application of 200 µM TEA.

 

Publications

2016 - Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations

icon pl  Patchliner publication in Scientific Reports (2016)

Authors: 
Han B., He K., Cai C., Tang Y., Yang L., Heinemann S.H., Hoshi T., Hou S.

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