NADH Dehydrogenase - NADH : Ubiquinone Oxidoreductase
H+ or Na+-translocating NADH dehydrogenase (NDH), a member of the Na+ transporting Mrp superfamily
In mammals, the enzyme contains 44 separate water soluble peripheral membrane proteins, which are anchored to the integral membrane constituents.
It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10). In eukaryotes, it is located in the inner mitochondrial membrane. It is one of the "entry enzymes" of cellular respiration or oxidative phosphorylation in the mitochondria and contains to the electron transport chain (ETC) complex I. The reaction catalyzed by complex I is:
NADH + H+ + CoQ + 4H+in→ NAD+ + CoQH2 + 4H+out
In this process, the complex translocates four protons across the inner membrane per molecule of oxidized NADH, helping to build the electrochemical potential difference used to produce ATP.