NaV1.3 | sodium voltage-gated channel alpha subunit 3
Alpha subunits consist of four homologous domains (I-IV) with six transmembrane alpha helices (S1–S6) and a pore-forming loop. One a subunit may associate with 1 or 2 b subunits to make up the channel.
NaV1.3: Background Information
NaV1.3 is abundantly expressed in neuronal tissues during embryonic and neonatal stages of development and is rare in adult tissues. After axonal transection, NaV1.3 is upregulated in dorsal root ganglia (DRG) neurons adding to the evidence that upregulation of NaV1.3 may play a role in rendering axotomized DRG neurons hyperexcitable, thus contributing to neuropathic pain. It is thought that the fast activation and inactivation kinetics of NaV1.3, together with its rapid repriming kinetics and persistent current component, contributes to the development of spontaneous ectopic discharges and sustained rates of firing characteristics of injured sensory nerves. NaV1.3 is TTX sensitive.
Brain neurons, peripheral neurons, injured neurons, spinal cord, heart
Excitability of neurons, generation of action potentials
Familial autism, deafness, epilepsy, pain
Contactin, β1 subunit, β3 subunit, β8 subunit, calmodulin, LRP, C1D
Tetrodotoxin, AFT-II, Vinpocetine, Flecainide, Lidocaine
Patch Clamp: whole cell, room temperature, State- and use-dependence
NaV channel analysis requires GigaOhm seals and a stable and low access resistance
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels. Pharmacol Rev 57: 397–409, Catterall, et al. 2005