NaV1.8 - State Dependent Inhibition

icon sp96   PE NaV1.8 State dep InhibitionSyncroPatch 384PE (a predecessor model of the SyncroPatch 384) data and applications:
Cells were kindly provided by Charles River.

State dependent inhibition of tetracaine on NaV1.8 currents was investigated. Measured on the SyncroPatch 384PE (a predecessor model of the SyncroPatch 384), the perforated cell patch methodology (Escin) and multi-hole chips were used and compared to single-whole chips. Using a state dependant pulse protocol, the IC50 value determined from the first pulse (C1) was calculated as 54.3 µM (Hill coefficient = 1.50), and from the second pulse (C2) as 1.27 µM (Hill coefficient = 0.62). 

 

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