nAChRa7 | nicotinic acetylcholine receptor alpha 7
The family has been devided into nicotinic acetylcholine receptors (ionotropic channels) and muscarinic acetylcholine receptors (metabotropic G-protein coupled receptors). Both subgroups are sensitive to acetylcholine.
Nicotinic acetylcholine receptors: As typical cys-loop receptors, acetylcholine receptor subunits contain four transmembrane spanning domains TM1-TM4. Five subunits form a pore, homomeric and heteromeric combinations are possible.17 vertebrate subunits have been identified: α genes: CHRNA1 - CHRNA10; β genes: CHRNB1 . CHRNB4, as well as CHRND (delta), CHRNE (epsilon), CHRNG (gamma)
Muscarinic acetylcholine receptors: 5 receptors have been described (M1 - M5), encoded by the 5 genes CHRM1 - CHRM5. These proteins contain seven transmembrane regions and do not form homo or heteromers.
AChRα7: Background Information
The neuronal alpha-7 nicotinic receptor, also known as the α7 receptor, is a type of nicotinic acetylcholine receptor implicated in long term memory, consisting entirely of α7 subunits. As with other nicotinic acetylcholine receptors, functional α7 receptors are pentameric (α7)5.
Brain, retina, spinal cord, peripheral neuronal tissues, including neurons of mammalian sympathetic ganglia, parasympathetic ganglia, sensory neurons such as the trigeminal ganglia and adrenal chromaffin cells
Mediates effects of acetylcholine and nicotine in specific regions of the brain, retina and spinal cord
Schizophrenia, Alzheimer's disease, Parkinson's, Tourette's Syndrome, depression
The receptor consists entirely of the α7 subunit, no further subunits are known
Protein RIC-3 (RIC3) promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface and is required for proper folding and assembly; Ly6/PLAUR domain-containing protein 6 (LYPD6) acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain and inhibits nicotine-induced Ca2+ influx through nAChRs.
Antagonists: DHβE, mecamylamine, α-bungarotoxin, α-conotoxin ImI, methyllycaconitine, α-conotoxin ArIB; Positive allosteric modulators: A-867744, LY2087101, NS1738, JNJ1930942, PNU-120596
Patch Clamp: whole cell, room temperature, physiological temperature
Reviews and Links
- Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function; Physiol Rev 89: 73–120, 2009; doi:10.1152/physrev.00015.2008, Albuquergue et al;
Transporter classification database:
Data and Applications