• P2X3

    Reproducable current traces from 1321 N1 cells expressing P2X3 receptors, activated by 100 ms application of 10 µM ATP (measured on the Port-a-Patch).

P2X2/ P2X3 - Block by suramin on the Patchliner

P2X23 1321N1Cells suramin PLicon pl   Patchliner data and applications: 
Cells were kindly supplied by Evotec AG, Hamburg, Germany

Block of P2X2/3 receptors by suramin. Suramin at increasing concentrations (1 μM - 1 mM) was pre-incubated and then co-applied with 30 μM ATP. Full recovery from block was achieved upon washout (data not shown). Concentration response curve (right) for suramin block, IC50 = 28.0 ± 5.3 μM (n = 7).

 

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