TREK-1 | K2P2.1 | Potassium Channel Subfamily K Member 2

Family:
Tandem-Pore Domain Potassium Channels

Subgroups:
Tandem pore domain K+ channels have been classified into six subfamilies; tandem pore domains in weak rectifying K+ channel (TWIK), TWIK-related K+ channel (TREK), TWIK-related acid-sensitive K+ channel (TASK), TWIK-related alkaline pH-activated K+ channel (TALK), tandem pore domain halothane-inhibted K+ channel (THIK), TWIK-releated spinal cord K+ channel (TRESK)
15 members: K2P1.1 (TWIK-1); K2P2.1 (TREK-1); K2P3.1 (TASK-1); K2P4.1 (TRAAK); K2P5.1 (TASK-2); K2P6.1 (TWIK-2); K2P7.1; K2P9.1 (TASK-3); K2P10.1 (TREK-2); K2P12.1 (THIK-2); K2P13.1 (THIK-1); K2P15.1 (TASK-5); K2P16.1 (TALK-1); K2P17.1 (TASK-2, TASK-4); K2P18.1 (TRIK, TRESK);

Topology:
The channel protein contains four transmembrane domains, which form two pore loops between domains 1–2 and 3–4. Two subunits associate to form a dimer with bilateral symmetry around the pore. Homodimers and heterodimers are possible.

Regulation:
Several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins

Application Notes

TREK-1 - "Activation and inhibition of TREK-1 on Nanion’s SyncroPatch 384PE"

icon sp96  SyncroPatch 384PE (a predecessor model of the SyncroPatch 384i) application note   logo pdf   (6.0 MB)
Cells were kindly provided by SB Drug Discovery.

Publications

2017 - Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

icon pap  Port-a-Patch and   icon vpp   Vesicle Prep Pro publication in Structure (2017)

Authors: 
Arya P, Jarerattanachat V., Clausen M.V., Schewe M., McClenaghan C., Argent L., Conrad L.J., Dong Y.Y., Pike A.C.W., Carpenter E.P., Baukrowitz T., Sansom M.S.P., Tucker S.J.

2016 - The potassium channels TASK2 and TREK1 regulate functional differentiation of murine skeletal muscle cells

icon pl  Patchliner publication in American Journal of Physiology - Cell Physiology (2016)

Authors: 
Afzali A.M., Ruck T., Herrmann A.M., Iking J., Sommer C., Kleinschnitz C., Preuβe C., Stenzel W., Budde T., Wiendl H., Bittner S., Meuth S.G.

2016 - pH-sensitive K+ channel TREK-1 is a novel target in pancreatic cancer

icon sp96  SyncroPatch 384PE (a predecessor model of SyncroPatch 384i) publication in Biochimica et Biophysica Acta (2016)

Authors: 
Sauter D.R.P., Sørensen C.E., Rapedius M., Brüggemann A., Novak I.

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