TRPC1 | Transient Receptor Potential Cation Channel Subfamily C Member 1
Family:
Transient receptor potential channels
Subgroups:
TRPC (TRPC1–TRPC7), TRPV (TRPV1-TRPV6), TRPA1, TRPM (TRPM1–TRPM8), TRPP (TRPP1–TRPP3, PKD1, PKDREJ, PKDL1–PKDL3), TRPML (TRPML1–TRPML3), TRPN
Topology:
Most TRP channels are composed of 6 transmembrane domains (helices) with intracellular N- and C-termini, non-selectively permeable to various cations
TRPC1: Background information
TRPC1, also called Short transient receptor potential channel 1 or Transient Receptor Protein 1, was the first mammalian Transient Receptor Potential channel to be identified. TRPC1 is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the phospholipase C system.
Gene:
TRPC1
Human Protein:
UniProt P48995
Tissue:
Ubiquitous expressed, vascular smooth mucle cells, endothelial cells
Function/ Application:
Regulation of cytosolic calcium ion concentration
Pathology:
Diabetic nephropathy, Parkinson's disease, Huntington's disease, Duchenne muscular dystrophy, cancer, seizures, Darier-White skin disease
Interaction:
TRPC3, TRPC4, TRPC5, TRPC7, STIM1, polycystic kidney disease 2, Homer protein homolog 3, Ras homolog gene family, member A (RhoA), inositol 1,4,5 triphosphate, Bone morphogenetic protein receptor, type IB
Modulator:
Thapsigargin, lanthanum, Optovin, gadolinium, SKF96365
Assays:
Patch Clamp: whole cell, extracellular perfusion
Recommended Reviews:International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels., Pharmacol Rev 55(4):591-6 Clapham, et al. 2003