TRPM7 | Transient Receptor Potential Cation Channel Subfamily M Member 7
Transient receptor potential channels
TRPC (TRPC1–TRPC7), TRPV (TRPV1-TRPV6), TRPA1, TRPM (TRPM1–TRPM8), TRPP (TRPP1–TRPP3, PKD1, PKDREJ, PKDL1–PKDL3), TRPML (TRPML1–TRPML3), TRPN
Most TRP channels are composed of 6 transmembrane domains (helices) with intracellular N- and C-termini, non-selectively permeable to various cations
TRPM7: Background information
TRPM7 is a divalent cation channel permeable to calcium and magnesium. The protein encoded by this TRPM7 is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis.
Widely expressed in mammalian cells, especially heart, pituitary, bone, adipose tissue, highest expression level in kidney
TRPM7 has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Furthermore, the channel is involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx and it may be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell.
Ophthalmomyiasis, Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, dementia, lateral sclerosis, cardiac fibrosis, atrial fibrillation, macrothrombocytopenia. TRPM7 plays a role in cancer cells including survival, cell cycle progression, proliferation, growth, migration, invasion, and epithelial-mesenchymal transition (EMT)
PLCB1, PLCB2, phosphorylates annexin 1, forms complexes in synaptic vesicles with synapsin I and synaptotagmin I and directly interacts with snapin, TRPM7 forms heterodimers with TRPM6.
carvacrol, H+ (extracellular), ADP, naltriben, PiP2, 2-APB, spermine, fingolimod, La3+
Patch Clamp: whole cell
Recommended Reviews:International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels., Pharmacol Rev 55(4):591-6 Clapham, et al. 2003