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19.10.2020 - Poster - Mechanical Stimulation in a 2D High-Throughput Contractility System

Mechanical Stimulation in a 2D High-Throughput Contractility System Induces Functional Changes in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

Introduction:
The use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSCCMs) to assess efficacy and cardiac safety of new drug candidates continues to increase. In this context, a new 2D high-throughput system, FLEXcyte 96, allows for contractility measurements of cells cultured in a more physiological environment, reflecting the mechanical conditions of the native human heart. This study aims to show the influence of mechanical stimulation on functional behavior of hiPSC-CMs. This aspect is of particular importance, as mechanical load acts as crucial growth regulator in the developing heart.


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