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05.08.2021: Poster Alert - Reliable identification of cardiac liability in drug discovery using automated patch clamp: Considerations and best practices for high throughput recordings of NaV 1.5

Reliable identification of cardiac liability in drug discovery using automated patch clamp: Considerations and best practices for high throughput recordings of NaV1.5

Abstract

For reliable identification of cardiac safety risk, compounds should be screened for effects on cardiac ion channels in addition to hERG including NaV1.5 and CaV1.2 Automated patch clamp (instruments are increasingly adopted for cardiac safety measurements but cross site and cross platform comparisons of IC50 values has identified the need for standardized protocols for reliable pharmacology In this study, we identified different parameters that might affect IC50s of compounds on NaV1.5 peak and late currents recorded using APC.

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