01.03.2019 | Drug Discovery for Ion Channels XIX

190301 event image BPS Satellite Meeting
Conference Venue
: Baltimore Convention Center, Maryland, USA

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Pre-registration is open.
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8:00 AM - 8:45 AM
Registration and Coffee, Light Breakfast

8:45 AM - 9:00 AM
Niels Fertig, Nanion Technologies
Welcome and Opening Remarks

Session I

Chair: David Dalrymple, SB Drug Discovery

9:00 AM - 9:45 AM
Keynote Speaker: Professor William Colmers, University of Alberta
Title: "NPY, HCN1 and Stress Resilience"

9:45 AM - 10:15 AM
Stephan Hess, Evotec AG
Title: "Use of Automated Patch Clamp Platforms to Support Ion Channel Drug Discovery"

10:15 AM - 10:45 AM
Marc Rogers, Metrion Biosciences
Title: "Successful Development of State-dependent Voltage-gated Ion Channel Modulators with in vivo Efficacy Using Automated Patch Clamp Assays for Primary Target Potency, Species and Gene Family Selectivity, and Cardiac Safety"

10:45 AM - 11:15 AM Coffee Break

Session II
Chair: Stephen Hess, Evotec AG

11:15 AM - 11:45 AM
Tianbo Li, Genentech
Title: "ProTx-II Inhibits Nav1.7 Through an Electrostatic Gating Modulation Mechanism"

11:45 AM - 12:15 PM
Hongkang Zhang, Q-State Biosciences
Title: "Target Based Screening on Nav Channels in Spiking HEK Cells, Using Optical Stimulation and Recording"

12:15 PM - 12:45 PM
David Dalrymple, SB Drug Discovery
Title: "Assessment of Diverse and Focussed Libraries for Ion Channel Screening"

12:45 PM - 1:45 PM Lunch

Session III
Chair: Marc Rogers, Metrion Biosciences

1:45 PM - 2:30 PM
Keynote Speaker: Professor Pancho Bezanilla, University of Chicago
Title: "Stimulating with Light"

2:30 PM – 3:00 PM
James Ellis, Nocion Therapeutics
Title: "Novel Small Molecule Nav Channel Blockers Selectively Targeting Nociceptors for the Treatment of Cough, Pain and Itch"

3:00 PM - 3:30 PM
Aneesh Karatt-Vellatt, Iontas
Title: "Knottin-antibody Fusion Proteins (KnotBodies): a Novel Biologics Class Targeting Kv1.3 (Autoimmunity), Nav1.7 (Chronic Pain) and ASIC1a (Stroke)"

3:30 PM - 4:00 PM Coffee Break

Session IV
Chair: James Ellis, Nocion Therapeutics

4:00 PM – 4:30 PM
Sam Goodchild, Xenon
Title: "Pharmacology of Voltage Sensor Targeting Nav1.6 Inhibitors"

4:30 PM - 5:00 PM
Fern Toh, Alkermes, Inc.
Title: "Application of High-throughput Automated Patch-clamp Techniques to Study Ion Channel Function in Cultured Primary Rat Cortical and Hypothalamic Neurons"

5:00 PM
Thomas Binzer, Sophion Bioscience
Closing Remarks


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