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29.11.2012 | Nanion's automated bilayer platform Orbit 16 and Ionera's MECA bilayer array enable the functional analysis of synthetic DNA-based nanopores

MUNICH and FREIBURG, GERMANY, November 29, 2012 -- In a landmark publication in Science, research on artificially designed DNA-origami nanopores has been published this week using Nanion's new Orbit 16 platform running Ionera's MECA1 bilayer array chip. The team of Prof. Simmel from the Technical University Munich has created nanometer-scale transmembrane ion channels by means of self-assembled DNA-based nanostructures. These “designer pores” have been reconstituted in lipid bilayers for functional characterization using the Orbit 16 for automated formation of, and recordings from 16 bilayers in parallel on Ionera's MECA1 array.

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MUNICH, GERMANY, November 08, 2012 -- Nanion’s automated patch clamp platforms are known for their high cell compatibility, even for primary cells and stem cells. Nanion now introduces “Nanion Approved Cells”, where commercially available cell lines from several providers have been evaluated and certified based on cell and platform performance. The approved cells can be directly purchased through Nanion, so that Nanion’s customers get a complete package of APC platform and validated assay.

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29.06.2012 | New Patchliner Publication: Toward a New Standard for Early Safety Assessment

MUNICH, GERMANY, June 29, 2012 -- In a recent publication, scientists at Hoffmann-La Roche, Basel, Switzerland, evaluated the Patchliner for safety testing of drugs affecting the hERG-channel, the cardiac ion channel most commonly associated with drug safety liability issues. In the performed study, the experiments were performed at physiological temperature (35 – 37°C), and the obtained data showed good correlation with pharmacology data recorded using conventional patch clamp.

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26.02.2012 | Nanion Acquires the SURFE²R Technology for Transporter Protein Analysis

MUNICH, GERMANY, February 26, 2012 -- Nanion acquires the well-established SURFE²R technology, allowing state-of-the-art measurements of transporter protein activity and function. The SURFE²R technology is an excellent enhancement to Nanion’s existing products which until now covered ion channels and nanopores.
Nanion Technologies is one of the leading providers of high quality automated patch clamp systems. Nanion’s efficient and versatile products drastically improve the data output in patch clamp-based ion channel screening, safety testing and scientific research. Since 2003, Nanion has launched three automated patch clamp platforms, the Port-a-Patch (2003), the Patchliner (2006), the SyncroPatch 96 (2010), and recently introduced the Orbit 16 – a device for parallel bilayer recordings. Existing products target ion channels and nanopores in cell- and cell-free membranes for highly detailed information about kinetics, function, and compound pharmacology.

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