Positive Inotropes - Omecamtiv Mecarbil myosin complex activation
FLEXcyte 96 data and applications:
Cells were kindly provided by NEXEL.
Omecamtiv mecarbil increased both the contraction amplitude as well as the duration of the contraction-relaxation-cycle, indicating the positive inotropic effect based on activation of the myosin complex. The symmetry of the contraction-relaxation-cycle was not changed.
Read the application note here.