• Port-a-Patch

    世界上最小的膜片钳系统
  • Port-a-Patch

    易学易用——教学的理想工具
  • Port-a-Patch

    可记录细胞、细胞器与脂双层
  • Port-a-Patch

    世界上首款平板芯片膜片钳设备
  • Port-a-Patch

    可进行内灌流——更换细胞内液的理想工具

Mitochondria - "Recordings from mitochondria and mitoplasts"

icon pap   Port-a-Patch application note   logo pdf   (0.4 MB)

Summary:

Mitochondria are often referred to as the “power house” of the cell since they are responsible for making most of the cell’s energy supply in the form of adenosine triphosphate (ATP). In addition to providing the cell with energy, mitochondria are thought to have roles in cell signalling, cellular differentiation and apoptosis. They have also been implicated in the pathophysiology of neurodegenerative disorders such as Parkinson’s Disease , and may also play a role in diabetes and in the ageing process. Mitochondria are usually rod shaped and range in size from approximately 1 - 10 µm. They have an outer membrane and a highly folded inner membrane. The outer membrane is highly permeable and contains one of the most well studied mitochondrial proteins, the voltage-dependent anion channel (VDAC). The inner membrane contains many ion channels, including the Ca2+ uniporter, a KATP channel, the Ca2+-activated K+ channel (KCa) and the inner membrane anion channel (IMAC). To study the mitochondrial inner membrane using the patch clamp technique, mitoplasts were formed. This is a process whereby the mitochondria are swelled, thus rupturing the outer membrane and exposing the inner membrane.

返回总览

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.