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2011 - Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide

icon pap   Port-a-Patch publication in Angewandte Chemie International Edition (2011)

Authors: 
Matsuoka S., Shinohara N., Takahashi T., Iida M., Inoue M.

 

Journal: 
Angew. Chem. Int. Ed. (2011) 50:4879-4883


Abstract: 

Polytheonamide B, the largest nonribosomal linear peptide identified to date, is a transmembrane channel-forming peptide. Nine of its substructures have now been chemically synthesized. The membrane-disrupting and ion-channel-forming sequences as well as the cytotoxicity-enhancing sequence have been identified.


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