• Port-a-Patch

  • Port-a-Patch

  • Port-a-Patch

  • Port-a-Patch

  • Port-a-Patch


TRPM8 - Cold activation of TRPM8 using the External Perfusion System and the Port-a-Patch

icon pap   Port-a-Patch application note:   logo pdf   (3.63 MB) 


TRPM8 is a member of the transient receptor potential channel (TRP) family. TRPM8 is known to be a thermosensitive channel, activated by cold temperatures (below ~25˚C) and ligands such as menthol, Eucalyptol and icilin1-4. It belongs to the melastatin subfamily of TRP channels5 and shows an outward rectification with a relatively high permeability for calcium ions and little selectivity between monovalent cations. Menthol, a secondary alcohol produced by the peppermint herb, Mentha piperita, is widely used in the food and pharmaceutical industries as a cooling/soothing compound and odorant.

Here we present data of hTRPM8 collected on the Port-a-Patch using cooled solution via the External Perfusion System. Cold activated hTRPM8 was blocked by capsazepine with an IC50 in good agreement with the literature.


We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.