The SyncroPatch 384 platform is a complete automated patch clamp system for recording from 384 wells simultaneously. The system comprises a state-of-the-art Biomek i5 pipetting robot with temperature-controlled deck positions, a temperature-controlled patch clamp module and Tecella amplifier with 384 channels. Current clamp is provided as standard along with PatchControl 384 and DataControl 384 software suite, NPC-384 chips and a reagent starter kit to ensure you get results from day 1. The system is covered by a 1 year warranty which includes both technical assistance and assay development support, which can be extended by optional annual service contracts.

The SyncroPatch 384 platform comes equipped with a sophisticated temperature control which includes 12 temperature-controlled deck positions, a cooled cell hotel and a temperature-controlled patch clamp module. The temperature range is 10 - 43°C. The solutions can be pre-warmed or cooled prior to addition to the chip to avoid large temperature changes upon solution addition.

The amplifier comprised within the SyncroPatch 384 can record in both voltage-clamp and current-clamp modes. With no extra costs or additional hardware required, the user can simply switch from voltage-clamp to current-clamp to record action potentials from electrically active cells, including stem cell-derived, and adult primary, cardiomyocytes.

With the 32-well mode of the SyncroPatch 384, you can literally turn the instrument into a lower throughput automated patch clamp instrument. Use part of the chip (in multiples of 32) and the rest of the chip can be stored and used at a later timepoint, with no change in the success rate. This is particularly useful for assay development and smaller screening projects.

SOL is an add-on for the SyncroPatch 384 that enables light activation of ion channels and control of caged or photoswitchable compounds. The system includes four independently controlled illuminators in a compact base that mounts directly on the SyncroPatch 384, enabling simultaneous illumination of up to 384 wells. The SOL is available with 10 wavelength options and supports single- or dual-wavelength setups per illuminator.